Macrolides which are used for the treatment of the infections of respiratory system, digestive system and uropoietic system in clinical application led to serious bacterial resistance because they were abused. This became major threat to successful treatment of infectious diseases. 用于治疗呼吸道感染和皮肤软组织感染的大环内酯类抗生素由于其在临床的广泛使用,特别是滥用,导致许多细菌对该类抗生素产生了严重的耐药性,给临床治疗带来了极大困难。